Patients with diabetes mellitus have a high-stress level, this is because the treatment is
undertaken such as diet, blood sugar control, drug consumption, and exercise. In addition, the risk of disease
complications that can be experienced by patients will also increase stress. Spiritual mindfulness based on benson
relaxation affects the formation of positive cognitive (perception) responses in the brain. A good stress perception
will stimulate the hypothalamus to release a series of hormones that cause modulation of the physiological barrier
of the immune response by decreasing the activation of the HPA axis and increasing activation of the
parasympathetic nerve through the vagal stimulation. The purpose of this study was to prove the influence of spiritual
mindfulness based on Benson relaxation in reducing stress levels of type 2 diabetes mellitus. This study was a
quasi-experimental study using the pretest-posttest with control group design method. Respondents in this study
were 60 type 2 DM sufferers and were taken by simple random sampling technique and divided into two groups
namely the intervention group and the control group. Stress level data is obtained using a questionnaire
measurement tool. The intervention group was given spiritual mindfulness based on Benson relaxation for four
weeks. The results of data analysis using t-Test with a significance of p <0.05. The stress level test results showed
a significant difference between the intervention group and the control group with p-value = 0,000. Mindfulness
spiritual intervention based on Benson relaxation is effective against stress levels of people with type 2 diabetes.